M
Martin Brown
Guest
On 15/02/2022 13:43, jlarkin@highlandsniptechnology.com wrote:
Synthetic RNA in the lab is getting close to understanding what the very
first self replicating RNA systems might have looked like. They have
made working examples that are capable of most of the required steps.
This article in Nature might clear up some of your misconceptions iff
you can be bothered to read it (free access).
https://www.nature.com/articles/35053176
Most of this detailed stuff is behind a paywall unless you have
university credentials or a subscription to nature:
https://www.nature.com/articles/321089a0
The first self replicating molecule only really has to occur once to
take over a lot of territory if the raw materials are present. After
that competition for resources and the inaccuracy of RNA copying allows
it to evolve to respond to environmental constraints.
There are also surprisingly a few examples of likely throwbacks from the
late RNA world stage that include some extremely large complicated RNA
only viruses that mostly parasitise amoeba now but which were
misclassified for a long time as unculturable bacteria because they
couldn\'t get them to multiply in the lab (and they were \"obviously\" too
big to be viruses). Pithoviruses and Pandoravirus being examples:
https://www.nationalgeographic.com/science/article/140716-giant-viruses-science-life-evolution-origins
https://www.nationalgeographic.com/science/article/130718-viruses-pandoraviruses-science-biology-evolution
They still have most of the bits present that would be needed in a fully
functioning RNA based cell independent of a host.
There may well be some more smoking guns for RNA world lying around.
Biologists have really only just begin to recognise them. They were only
noticed as something very unusual when a virus specialist looked at an
electron micrograph of an infected amoeba!
--
Regards,
Martin Brown
On Mon, 14 Feb 2022 09:51:29 +0000, Martin Brown
\'\'\'newspam\'\'\'@nonad.co.uk> wrote:
On 13/02/2022 17:31, David Brown wrote:
On 13/02/2022 17:51, Martin Brown wrote:
You can haggle about whether or not they are truly alive because they
need to hijack a cell to replicate (at least all the ones I know of do).
There are some viruses that are so simple that they can\'t hijack a
cell\'s replication systems - they hijack another virus\'s hijacking! In
a sense, they are small viruses that infect other large viruses. Fun stuff.
And little fleas have lesser fleas upon their backs to bite \'em.
Eventually in a quantised world they get too small to be viable.
Viral phages that attack bacteria are also quite interesting and some of
them may yet have therapeutic value. Progress in this field is slow but
steady as the various pieces are found and understood.
https://www.nature.com/articles/d41586-019-01880-6
The viruses that we see today have co-evolved with their hosts for many
billions of years. The earliest ones would have been much much simpler.
Is there evidence for that?
Synthetic RNA in the lab is getting close to understanding what the very
first self replicating RNA systems might have looked like. They have
made working examples that are capable of most of the required steps.
This article in Nature might clear up some of your misconceptions iff
you can be bothered to read it (free access).
https://www.nature.com/articles/35053176
Most of this detailed stuff is behind a paywall unless you have
university credentials or a subscription to nature:
https://www.nature.com/articles/321089a0
The first self replicating molecule only really has to occur once to
take over a lot of territory if the raw materials are present. After
that competition for resources and the inaccuracy of RNA copying allows
it to evolve to respond to environmental constraints.
There are also surprisingly a few examples of likely throwbacks from the
late RNA world stage that include some extremely large complicated RNA
only viruses that mostly parasitise amoeba now but which were
misclassified for a long time as unculturable bacteria because they
couldn\'t get them to multiply in the lab (and they were \"obviously\" too
big to be viruses). Pithoviruses and Pandoravirus being examples:
https://www.nationalgeographic.com/science/article/140716-giant-viruses-science-life-evolution-origins
https://www.nationalgeographic.com/science/article/130718-viruses-pandoraviruses-science-biology-evolution
They still have most of the bits present that would be needed in a fully
functioning RNA based cell independent of a host.
There may well be some more smoking guns for RNA world lying around.
Biologists have really only just begin to recognise them. They were only
noticed as something very unusual when a virus specialist looked at an
electron micrograph of an infected amoeba!
--
Regards,
Martin Brown