COVID-19 vaccine protects monkeys from new coronavirus, Chin

[Bill Sloman]

On Monday, April 27, 2020 at 12:35:31 AM UTC+10, bloggs.fre...@gmail.com wrote:

On Saturday, April 25, 2020 at 11:41:37 PM UTC-4, Bill Sloman wrote:
On Sunday, April 26, 2020 at 1:55:48 AM UTC+10, bloggs.fre...@gmail.com wrote:
On Saturday, April 25, 2020 at 10:11:40 AM UTC-4, Bill Sloman wrote:
On Saturday, April 25, 2020 at 10:19:25 PM UTC+10, bloggs.fre...@gmail.com wrote:
On Friday, April 24, 2020 at 8:30:35 PM UTC-4, Bill Sloman wrote:
On Saturday, April 25, 2020 at 9:50:52 AM UTC+10, bloggs.fre...@gmail.com wrote:
On Friday, April 24, 2020 at 12:40:49 AM UTC-4, Bill Sloman wrote:
On Friday, April 24, 2020 at 9:44:13 AM UTC+10, bloggs.fre...@gmail.com wrote:

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Chief scientists and CEOs at major pharmaceuticals involved in this kind of work would be start.

They may be feeding you snippets of information, but you aren't doing well at making sense of them.

LOL- and this conclusion coming from someone who sets the record for being consistently wrong about every last thing you think you know about immunology. Just goes to show how powerfully destructive the forces of delusion can be.

Fred confuses "not agreeing with his silly misapprehensions" with being "consistently wrong". Just goes to show how powerfully destructive the forces of delusion can be.

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Bill Sloman, Sydney

 

[Bill Sloman]

On Monday, April 27, 2020 at 3:04:05 AM UTC+10, Cursitor Doom wrote:

On Sun, 26 Apr 2020 07:35:26 -0700, bloggs.fredbloggs.fred wrote:

LOL- and this conclusion coming from someone who sets the record for
being consistently wrong about every last thing you think you know about
immunology.

That's immaterial to Bill. He doesn't care if he's in the right or not,
he just gets off on dragging out pointless arguments and wasting other
people's time.

Actually I do care about getting things right. Cursitor Doom doesn't have a clue what might be right or wrong - he relies on Russia Today and the Daily Mail for his intellectual baseline - so he's unaware of this.

Fred Bloggs is a more complex case. He's being fed snippets of data about immunological questions which he doesn't understand, and feels hurt when I point this out.

He recently told us that the corona virus spike protein doesn't mutate, which is wrong.

What he meant was that it is conserved - it has to work for the virus to be able to reproduce, so while it does mutate (like every other protein that viral nucleotides encode) only a virus that inherits a workable version gets to survive.

The SARS spike protein is subtly different from the Covid-19 spike protein, so both have mutated away from the spike protein in the ancestral bat virus (which can't infect human cells) but Fred was too dumb to realise this.

--
Bill Sloman, Sydney

 

On Sunday, April 26, 2020 at 11:34:05 PM UTC-4, Bill Sloman wrote:

On Monday, April 27, 2020 at 3:04:05 AM UTC+10, Cursitor Doom wrote:
On Sun, 26 Apr 2020 07:35:26 -0700, bloggs.fredbloggs.fred wrote:

LOL- and this conclusion coming from someone who sets the record for
being consistently wrong about every last thing you think you know about
immunology.

That's immaterial to Bill. He doesn't care if he's in the right or not,
he just gets off on dragging out pointless arguments and wasting other
people's time.

Actually I do care about getting things right. Cursitor Doom doesn't have a clue what might be right or wrong - he relies on Russia Today and the Daily Mail for his intellectual baseline - so he's unaware of this.

Fred Bloggs is a more complex case. He's being fed snippets of data about immunological questions which he doesn't understand, and feels hurt when I point this out.

He recently told us that the corona virus spike protein doesn't mutate, which is wrong.

What he meant was that it is conserved - it has to work for the virus to be able to reproduce, so while it does mutate (like every other protein that viral nucleotides encode) only a virus that inherits a workable version gets to survive.

The SARS spike protein is subtly different from the Covid-19 spike protein, so both have mutated away from the spike protein in the ancestral bat virus (which can't infect human cells) but Fred was too dumb to realise this.

More of your simple-minded misapprehensions. The spike protein is a huge molecule and the portion of it used for bonding to the ACE-2 receptor has to be conserved or you'll have no cell fusion.
Then this crazy idea as if the mutation process has intelligence behind it is equally idiotic. Mutations result from accidents during replication. The more complicated the replication process, the greater the chance for accidents in gene mixing or something else. The immune system naturally and inadvertently selects for those accidents that best evade it. DUH!

--
Bill Sloman, Sydney

 

[Bill Sloman]

On Tuesday, April 28, 2020 at 1:38:20 AM UTC+10, bloggs.fre...@gmail.com wrote:

On Sunday, April 26, 2020 at 11:34:05 PM UTC-4, Bill Sloman wrote:
On Monday, April 27, 2020 at 3:04:05 AM UTC+10, Cursitor Doom wrote:
On Sun, 26 Apr 2020 07:35:26 -0700, bloggs.fredbloggs.fred wrote:

LOL- and this conclusion coming from someone who sets the record for
being consistently wrong about every last thing you think you know about
immunology.

That's immaterial to Bill. He doesn't care if he's in the right or not,
he just gets off on dragging out pointless arguments and wasting other
people's time.

Actually I do care about getting things right. Cursitor Doom doesn't have a clue what might be right or wrong - he relies on Russia Today and the Daily Mail for his intellectual baseline - so he's unaware of this.

Fred Bloggs is a more complex case. He's being fed snippets of data about immunological questions which he doesn't understand, and feels hurt when I point this out.

He recently told us that the corona virus spike protein doesn't mutate, which is wrong.

What he meant was that it is conserved - it has to work for the virus to be able to reproduce, so while it does mutate (like every other protein that viral nucleotides encode) only a virus that inherits a workable version gets to survive.

The SARS spike protein is subtly different from the Covid-19 spike protein, so both have mutated away from the spike protein in the ancestral bat virus (which can't infect human cells) but Fred was too dumb to realise this.

More of your simple-minded misapprehensions. The spike protein is a huge molecule and the portion of it used for bonding to the ACE-2 receptor has to be conserved or you'll have no cell fusion.

But it can't be perfectly conserved, because Covid-19 can infect human cells and the ancestral bat virus couldn't.

Congratulations on having woken up to the difference between "conserved" and "not mutated".

> Then this crazy idea as if the mutation process has intelligence behind it is equally idiotic.

That's John Larkin's lunacy, not mine.

> Mutations result from accidents during replication. The more complicated the replication process, the greater the chance for accidents in gene mixing or something else.

RNA replication is more accident-prone than DNA replication. Most viruses have a small enough genome (33k units in corona viruses) that they can live with frequency of copying errors you get when replicating RNA.

The corona viruses encode their own replication machinery

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369385/

and that can get messed by defects during copying. The replicator sequence is going to be highly conserved, but it is also messy. Anything that made it "more complicated" would clearly stop it working.

It's probably sufficient to observe that any copying process imperfect enough to occasionally put the wrong amino acid into the RNA sequence being produced could explain all the variation we see. There will be a whole lot more variation we don't see because those variants weren't viable.

You still don't seem to understand what you are talking about.

--
Bill Sloman, Sydney