Breathing Low Oxygen Air For Longevity...

[Fred Bloggs]

On Tuesday, November 22, 2022 at 12:25:20 PM UTC-5, Lamont Cranston wrote:

Probably has to do with simulating the air in the high
Urals where people have been observed to live to 150...

Hope we live long enough to find out!
Breathing HIGH Oxygen Air For Longevity
https://www.google.com/search?client=firefox-b-1-d&q=hyperbaric+chamber+life+extension
Mikek

-hyper means excess
-baric means pressure

hyperbaric means high pressure air, not more oxygenated air

Too rich of an O2 concentration can shut down the autonomic breathing system which obviously will not contribute to the longevity of the patient.

Real information on the subject:
https://www.mayoclinic.org/tests-procedures/hyperbaric-oxygen-therapy/about/pac-20394380

There\'s a lot of hype out there. Looks like it\'s phony research published by employees of phony therapy clinics

 

[Fred Bloggs]

On Monday, November 21, 2022 at 12:05:59 PM UTC-5, John Larkin wrote:

On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joeg...@comcast.net
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jla...@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they world otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Joe Gwinn
Natural selection favors those who breed, not those who get very old.

That\'s a hilarious statement. Natural selection pertains to species survival, not individuals.

Natural selection favors people who to the manner born innately know how to grow food for themselves. Right.

There must be an evolutionary reason why nearly all critters get old
and die.

Yeah there is. Life as we know it is based on DNA chemistry, which apparently favors minimal complexity in its self-sustaining lifeforms. the economy model. Interestingly in the human model, the most phylogenetically recent cell structures exhibit the fastest aging. The human DNA model is under constant assault from day one. Damage happens, Damage accumulates. Damage can even beget more damage. The system doesn\'t exist in a vacuum, stuff from the external world causes damage. Your mindset insofar it has a very strong influence on critical endocrine system function can easily cause pervasive damage. There\'s no end to all the damage. This is only going to go on for so long before everything calls it quits. In the last moments ( which can last days) there is system wide signaling broadcast that tells all your cells to let go and stop functioning, which is exactly what they do, as obedient as they are. That is called a peaceful death. Don\'t complain, it could be worse.

 

[John Larkin]

On Tue, 22 Nov 2022 17:04:03 -0800 (PST), Fred Bloggs
<bloggs.fredbloggs.fred@gmail.com> wrote:

On Monday, November 21, 2022 at 12:05:59 PM UTC-5, John Larkin wrote:
On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joeg...@comcast.net
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jla...@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they world otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Joe Gwinn
Natural selection favors those who breed, not those who get very old.

That\'s a hilarious statement. Natural selection pertains to species survival, not individuals.

Natural selection favors people who to the manner born innately know how to grow food for themselves. Right.


There must be an evolutionary reason why nearly all critters get old
and die.

Yeah there is. Life as we know it is based on DNA chemistry, which apparently favors minimal complexity in its self-sustaining lifeforms. the economy model. Interestingly in the human model, the most phylogenetically recent cell structures exhibit the fastest aging. The human DNA model is under constant assault from day one. Damage happens, Damage accumulates. Damage can even beget more damage. The system doesn\'t exist in a vacuum, stuff from the external world causes damage. Your mindset insofar it has a very strong influence on critical endocrine system function can easily cause pervasive damage. There\'s no end to all the damage. This is only going to go on for so long before everything calls it quits. In the last moments ( which can last days) there is system wide signaling broadcast that tells all your cells to let go and stop functioning, which is exactly what they do, as obedient as they are. That is called a peaceful death. Don\'t complain, it could be worse.

Given two DNA-damaged parents, descended from DNA-damaged ancestors,
how do they create a fresh undamaged baby?

The oldest mother on record was almost 67. The oldest father, 101.

Cloning also creates a fresh young critter. Somehow the accumulated
DNA damage is reversed.

https://dolly.roslin.ed.ac.uk/facts/the-life-of-dolly/index.html

 

[Fred Bloggs]

On Tuesday, November 22, 2022 at 9:39:17 PM UTC-5, John Larkin wrote:

On Tue, 22 Nov 2022 17:04:03 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

On Monday, November 21, 2022 at 12:05:59 PM UTC-5, John Larkin wrote:
On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joeg...@comcast.net
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jla...@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they world otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Joe Gwinn
Natural selection favors those who breed, not those who get very old.

That\'s a hilarious statement. Natural selection pertains to species survival, not individuals.

Natural selection favors people who to the manner born innately know how to grow food for themselves. Right.


There must be an evolutionary reason why nearly all critters get old
and die.

Yeah there is. Life as we know it is based on DNA chemistry, which apparently favors minimal complexity in its self-sustaining lifeforms. the economy model. Interestingly in the human model, the most phylogenetically recent cell structures exhibit the fastest aging. The human DNA model is under constant assault from day one. Damage happens, Damage accumulates. Damage can even beget more damage. The system doesn\'t exist in a vacuum, stuff from the external world causes damage. Your mindset insofar it has a very strong influence on critical endocrine system function can easily cause pervasive damage. There\'s no end to all the damage. This is only going to go on for so long before everything calls it quits. In the last moments ( which can last days) there is system wide signaling broadcast that tells all your cells to let go and stop functioning, which is exactly what they do, as obedient as they are. That is called a peaceful death. Don\'t complain, it could be worse.
Given two DNA-damaged parents, descended from DNA-damaged ancestors,
how do they create a fresh undamaged baby?

The oldest mother on record was almost 67. The oldest father, 101.

Cloning also creates a fresh young critter. Somehow the accumulated
DNA damage is reversed.

https://dolly.roslin.ed.ac.uk/facts/the-life-of-dolly/index.html

There are somatic cells and germ cells. The germ cells have all kinds of protection to maintain DNA integrity the somatic cells don\'t have. There is no DNA damage to reverse.

 

[Fred Bloggs]

On Tuesday, November 22, 2022 at 9:39:17 PM UTC-5, John Larkin wrote:

On Tue, 22 Nov 2022 17:04:03 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

On Monday, November 21, 2022 at 12:05:59 PM UTC-5, John Larkin wrote:
On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joeg...@comcast.net
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jla...@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they world otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Joe Gwinn
Natural selection favors those who breed, not those who get very old.

That\'s a hilarious statement. Natural selection pertains to species survival, not individuals.

Natural selection favors people who to the manner born innately know how to grow food for themselves. Right.


There must be an evolutionary reason why nearly all critters get old
and die.

Yeah there is. Life as we know it is based on DNA chemistry, which apparently favors minimal complexity in its self-sustaining lifeforms. the economy model. Interestingly in the human model, the most phylogenetically recent cell structures exhibit the fastest aging. The human DNA model is under constant assault from day one. Damage happens, Damage accumulates. Damage can even beget more damage. The system doesn\'t exist in a vacuum, stuff from the external world causes damage. Your mindset insofar it has a very strong influence on critical endocrine system function can easily cause pervasive damage. There\'s no end to all the damage. This is only going to go on for so long before everything calls it quits. In the last moments ( which can last days) there is system wide signaling broadcast that tells all your cells to let go and stop functioning, which is exactly what they do, as obedient as they are. That is called a peaceful death. Don\'t complain, it could be worse.
Given two DNA-damaged parents, descended from DNA-damaged ancestors,
how do they create a fresh undamaged baby?

The oldest mother on record was almost 67. The oldest father, 101.

Cloning also creates a fresh young critter. Somehow the accumulated
DNA damage is reversed.

That\'s the thing with cloning, the result isn\'t \"fresh.\" The Dolly sheep was born with \"old\" DNA. Maybe they\'ve improved the process since then.

https://dolly.roslin.ed.ac.uk/facts/the-life-of-dolly/index.html

 

[Martin Brown]

On 22/11/2022 17:25, Lamont Cranston wrote:

Probably has to do with simulating the air in the high
Urals where people have been observed to live to 150...


Hope we live long enough to find out!
Breathing HIGH Oxygen Air For Longevity
https://www.google.com/search?client=firefox-b-1-d&q=hyperbaric+chamber+life+extension
Mikek

That is almost certainly quackery. There is an advantage to using
enriched oxygen atmospheres to keep people\'s blood oxygen level high
enough not to damage major organs but any more than that for an extended
period and you risk causing serious damage.

Oxygen is essential but here is huge tension between burning fuel in
cells to make energy and the nasty reactive species that it produces.

IN the Atacama desert the folk working on the supercomputer need
supplementary oxygen since they are well into the dead zone at 16500\'

https://public.nrao.edu/gallery/oxygen-required/

No observatory was that high up in my day. Although falling asleep at
that sort of altitude they were at could be potentially fatal (and
indistinguishable from passing out due to lack of oxygen).

One thing that is certainly true is that a whiff of near pure oxygen at
high altitude observatories (kept for reviving/supporting anyone who
passes out or becomes irrational due to altitude sickness while you get
them off the mountain) results in a noticeable in sensitivity of the
retina. Well beyond what a you can see with the naked eye. It was
frowned upon to do this trick.

--
Regards,
Martin Brown

 

[Martin Brown]

On 23/11/2022 00:30, Fred Bloggs wrote:

On Tuesday, November 22, 2022 at 12:25:20 PM UTC-5, Lamont Cranston
wrote:
Probably has to do with simulating the air in the
high Urals where people have been observed to live
to 150...

Hope we live long enough to find out! Breathing HIGH Oxygen Air For
Longevity
https://www.google.com/search?client=firefox-b-1-d&q=hyperbaric+chamber+life+extension


Mikek

-hyper means excess -baric means pressure

hyperbaric means high pressure air, not more oxygenated air

In effect it means both. Partial pressure of O2 goes up as the pressure
goes up (as does the tendency of nitrogen to dissolve in water).

Too rich of an O2 concentration can shut down the autonomic breathing
system which obviously will not contribute to the longevity of the
patient.

When you get to partial pressure of O2 = 1 atmosphere then the effects
are pretty similar to having 1 atmosphere of pure oxygen. Early
experimenters with Van der Graaf machine found this out the hard way.

Increasing atmospheric pressure to raise the breakdown potential of air
was used in the early days. Worked fine until there was a spark!

--
Regards,
Martin Brown

 

[Martin Brown]

On 23/11/2022 02:39, John Larkin wrote:

On Tue, 22 Nov 2022 17:04:03 -0800 (PST), Fred Bloggs
bloggs.fredbloggs.fred@gmail.com> wrote:

On Monday, November 21, 2022 at 12:05:59 PM UTC-5, John Larkin
wrote:

There must be an evolutionary reason why nearly all critters get
old and die.

Yeah there is. Life as we know it is based on DNA chemistry, which
apparently favors minimal complexity in its self-sustaining
lifeforms. the economy model. Interestingly in the human model, the
most phylogenetically recent cell structures exhibit the fastest
aging. The human DNA model is under constant assault from day one.
Damage happens, Damage accumulates. Damage can even beget more
damage. The system doesn\'t exist in a vacuum, stuff from the
external world causes damage. Your mindset insofar it has a very
strong influence on critical endocrine system function can easily
cause pervasive damage. There\'s no end to all the damage. This is
only going to go on for so long before everything calls it quits.
In the last moments ( which can last days) there is system wide
signaling broadcast that tells all your cells to let go and stop
functioning, which is exactly what they do, as obedient as they
are. That is called a peaceful death. Don\'t complain, it could be
worse.

Given two DNA-damaged parents, descended from DNA-damaged ancestors,
how do they create a fresh undamaged baby?

Actually they don\'t.

There are plenty of very nasty hereditary diseases that pass on down the
germ line. Cystic fibrosis, sickle cell anaemia, haemophilia and various
nasty mitochondrial diseases that screw up the metabolism.

> The oldest mother on record was almost 67. The oldest father, 101.

Risk of Down\'s syndrome increases rapidly once the mother is 35+ - see
figure 1 here:

https://www.aafp.org/pubs/afp/issues/2000/0815/p825.html

Fertilised eggs don\'t develop into embryos unless they have pretty much
all the right bits to do so. Many major genetic defects are weeded out
early on in gestation.

Cloning also creates a fresh young critter. Somehow the accumulated
DNA damage is reversed.

https://dolly.roslin.ed.ac.uk/facts/the-life-of-dolly/index.html

The accumulated damage is *not* completely reversed. Her DNA wasn\'t as
well protected as a normal lamb would have been at 1 year old:

https://www.ed.ac.uk/roslin/about/dolly/facts/life-of-dolly#:~:text=DNA%20to%20more%20damage.

However, it was a retrovirus induced lung cancer that did for her in the
end. Nothing to do with being a clone. Other sheep were also affected.

--
Regards,
Martin Brown

 

[Fred Bloggs]

On Wednesday, November 23, 2022 at 7:41:23 AM UTC-5, Martin Brown wrote:

On 23/11/2022 00:30, Fred Bloggs wrote:
On Tuesday, November 22, 2022 at 12:25:20 PM UTC-5, Lamont Cranston
wrote:
Probably has to do with simulating the air in the
high Urals where people have been observed to live
to 150...

Hope we live long enough to find out! Breathing HIGH Oxygen Air For
Longevity
https://www.google.com/search?client=firefox-b-1-d&q=hyperbaric+chamber+life+extension


Mikek

-hyper means excess -baric means pressure

hyperbaric means high pressure air, not more oxygenated air
In effect it means both. Partial pressure of O2 goes up as the pressure
goes up (as does the tendency of nitrogen to dissolve in water).

Too rich of an O2 concentration can shut down the autonomic breathing
system which obviously will not contribute to the longevity of the
patient.
When you get to partial pressure of O2 = 1 atmosphere then the effects
are pretty similar to having 1 atmosphere of pure oxygen. Early
experimenters with Van der Graaf machine found this out the hard way.

Increasing atmospheric pressure to raise the breakdown potential of air
was used in the early days. Worked fine until there was a spark!

Aside from the explosion hazard, the hyperbaric chamber should have the same O2 concentration as room air at 1atm 21%. Since the therapy is in common use in standard medical practice, there obviously is nothing hazardous about it. Where things go wrong is when they displace most of the air mixture with O2, which is easily done with an intubation respirator or even a canula administration.

\"Breathing in higher oxygen concentrations can cause oxygen toxicity. Oxygen toxicity can affect all the body\'s organs but most often causes damage to the lungs, eyes, and brain. Most people recover from oxygen toxicity. But it\'s still a good idea to avoid high oxygen concentrations when possible.\"

\"Oxygen toxicity can cause a variety of complications affecting multiple organ systems. CNS complications primarily include tonic-clonic convulsions and amnesia. Pulmonary sequelae range from mild tracheobronchitis and absorptive atelectasis to diffuse alveolar damage that is indistinguishable from ARDS. \" ARDS is acute respiratory distress syndrome, and you really want to avoid that one.

https://www.ncbi.nlm.nih.gov/books/NBK430743/#:~:text=Oxygen%20toxicity%20can%20cause%20a,that%20is%20indistinguishable%20from%20ARDS.

Some background on lung volume:
https://en.wikipedia.org/wiki/Lung_volumes

You can see that roughly, and on average of course, you\'re capable of inflating your lungs to ~7x the air volume at rest. Max hyperbaric molar multiplier is ~2-3. So you would have to work real hard to poison yourself in a hyperbaric chamber.

--
Regards,
Martin Brown

 

[Fred Bloggs]

On Wednesday, November 23, 2022 at 8:03:24 AM UTC-5, Martin Brown wrote:

On 23/11/2022 02:39, John Larkin wrote:
On Tue, 22 Nov 2022 17:04:03 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

On Monday, November 21, 2022 at 12:05:59 PM UTC-5, John Larkin
wrote:

There must be an evolutionary reason why nearly all critters get
old and die.

Yeah there is. Life as we know it is based on DNA chemistry, which
apparently favors minimal complexity in its self-sustaining
lifeforms. the economy model. Interestingly in the human model, the
most phylogenetically recent cell structures exhibit the fastest
aging. The human DNA model is under constant assault from day one.
Damage happens, Damage accumulates. Damage can even beget more
damage. The system doesn\'t exist in a vacuum, stuff from the
external world causes damage. Your mindset insofar it has a very
strong influence on critical endocrine system function can easily
cause pervasive damage. There\'s no end to all the damage. This is
only going to go on for so long before everything calls it quits.
In the last moments ( which can last days) there is system wide
signaling broadcast that tells all your cells to let go and stop
functioning, which is exactly what they do, as obedient as they
are. That is called a peaceful death. Don\'t complain, it could be
worse.

Given two DNA-damaged parents, descended from DNA-damaged ancestors,
how do they create a fresh undamaged baby?
Actually they don\'t.

There are plenty of very nasty hereditary diseases that pass on down the
germ line. Cystic fibrosis, sickle cell anaemia, haemophilia and various
nasty mitochondrial diseases that screw up the metabolism.
The oldest mother on record was almost 67. The oldest father, 101.
Risk of Down\'s syndrome increases rapidly once the mother is 35+ - see
figure 1 here:

https://www.aafp.org/pubs/afp/issues/2000/0815/p825.html

Fertilised eggs don\'t develop into embryos unless they have pretty much
all the right bits to do so. Many major genetic defects are weeded out
early on in gestation.
Cloning also creates a fresh young critter. Somehow the accumulated
DNA damage is reversed.

https://dolly.roslin.ed.ac.uk/facts/the-life-of-dolly/index.html
The accumulated damage is *not* completely reversed. Her DNA wasn\'t as
well protected as a normal lamb would have been at 1 year old:

https://www.ed.ac.uk/roslin/about/dolly/facts/life-of-dolly#:~:text=DNA%20to%20more%20damage.

However, it was a retrovirus induced lung cancer that did for her in the
end. Nothing to do with being a clone. Other sheep were also affected.

Mother Nature doesn\'t want real old people reproducing a child they\'ll never live to see through to adulthood.

--
Regards,
Martin Brown

 

[Martin Brown]

On 23/11/2022 18:01, Fred Bloggs wrote:

On Wednesday, November 23, 2022 at 7:41:23 AM UTC-5, Martin Brown
wrote:
On 23/11/2022 00:30, Fred Bloggs wrote:
On Tuesday, November 22, 2022 at 12:25:20 PM UTC-5, Lamont
Cranston wrote:
Probably has to do with simulating the air in
the high Urals where people have been observed
to live to 150...

Hope we live long enough to find out! Breathing HIGH Oxygen Air
For Longevity
https://www.google.com/search?client=firefox-b-1-d&q=hyperbaric+chamber+life+extension




Mikek

-hyper means excess -baric means pressure

hyperbaric means high pressure air, not more oxygenated air
In effect it means both. Partial pressure of O2 goes up as the
pressure goes up (as does the tendency of nitrogen to dissolve in
water).

Too rich of an O2 concentration can shut down the autonomic
breathing system which obviously will not contribute to the
longevity of the patient.
When you get to partial pressure of O2 = 1 atmosphere then the
effects are pretty similar to having 1 atmosphere of pure oxygen.
Early experimenters with Van der Graaf machine found this out the
hard way.

Increasing atmospheric pressure to raise the breakdown potential of
air was used in the early days. Worked fine until there was a
spark!

Aside from the explosion hazard, the hyperbaric chamber should have
the same O2 concentration as room air at 1atm 21%. Since the therapy
is in common use in standard medical practice, there obviously is
nothing hazardous about it. Where things go wrong is when they
displace most of the air mixture with O2, which is easily done with
an intubation respirator or even a canula administration.

You have completely failed to understand.

The partial pressure of oxygen determines the reaction rate so once you
have 5 atm of normal air it is functionally equivalent to 1atm of pure
O2 give or take a very small diluting effect from the inert nitrogen.

It applies to fires in pressurised environments.

\"Breathing in higher oxygen concentrations can cause oxygen toxicity.
Oxygen toxicity can affect all the body\'s organs but most often
causes damage to the lungs, eyes, and brain. Most people recover from
oxygen toxicity. But it\'s still a good idea to avoid high oxygen
concentrations when possible.\"

\"Oxygen toxicity can cause a variety of complications affecting
multiple organ systems. CNS complications primarily include
tonic-clonic convulsions and amnesia. Pulmonary sequelae range from
mild tracheobronchitis and absorptive atelectasis to diffuse alveolar
damage that is indistinguishable from ARDS. \" ARDS is acute
respiratory distress syndrome, and you really want to avoid that
one.

https://www.ncbi.nlm.nih.gov/books/NBK430743/#:~:text=Oxygen%20toxicity%20can%20cause%20a,that%20is%20indistinguishable%20from%20ARDS.

Some background on lung volume:
https://en.wikipedia.org/wiki/Lung_volumes

You can see that roughly, and on average of course, you\'re capable of
inflating your lungs to ~7x the air volume at rest. Max hyperbaric
molar multiplier is ~2-3. So you would have to work real hard to
poison yourself in a hyperbaric chamber.

Depends how hyperbaric it was. A few percent won\'t make much difference.

--
Regards,
Martin Brown

 

[Martin Brown]

On 23/11/2022 18:03, Fred Bloggs wrote:

On Wednesday, November 23, 2022 at 8:03:24 AM UTC-5, Martin Brown wrote:
On 23/11/2022 02:39, John Larkin wrote:
On Tue, 22 Nov 2022 17:04:03 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

On Monday, November 21, 2022 at 12:05:59 PM UTC-5, John Larkin
wrote:

There must be an evolutionary reason why nearly all critters get
old and die.

Yeah there is. Life as we know it is based on DNA chemistry, which
apparently favors minimal complexity in its self-sustaining
lifeforms. the economy model. Interestingly in the human model, the
most phylogenetically recent cell structures exhibit the fastest
aging. The human DNA model is under constant assault from day one.
Damage happens, Damage accumulates. Damage can even beget more
damage. The system doesn\'t exist in a vacuum, stuff from the
external world causes damage. Your mindset insofar it has a very
strong influence on critical endocrine system function can easily
cause pervasive damage. There\'s no end to all the damage. This is
only going to go on for so long before everything calls it quits.
In the last moments ( which can last days) there is system wide
signaling broadcast that tells all your cells to let go and stop
functioning, which is exactly what they do, as obedient as they
are. That is called a peaceful death. Don\'t complain, it could be
worse.

Given two DNA-damaged parents, descended from DNA-damaged ancestors,
how do they create a fresh undamaged baby?
Actually they don\'t.

There are plenty of very nasty hereditary diseases that pass on down the
germ line. Cystic fibrosis, sickle cell anaemia, haemophilia and various
nasty mitochondrial diseases that screw up the metabolism.
The oldest mother on record was almost 67. The oldest father, 101.
Risk of Down\'s syndrome increases rapidly once the mother is 35+ - see
figure 1 here:

https://www.aafp.org/pubs/afp/issues/2000/0815/p825.html

Fertilised eggs don\'t develop into embryos unless they have pretty much
all the right bits to do so. Many major genetic defects are weeded out
early on in gestation.
Cloning also creates a fresh young critter. Somehow the accumulated
DNA damage is reversed.

https://dolly.roslin.ed.ac.uk/facts/the-life-of-dolly/index.html
The accumulated damage is *not* completely reversed. Her DNA wasn\'t as
well protected as a normal lamb would have been at 1 year old:

https://www.ed.ac.uk/roslin/about/dolly/facts/life-of-dolly#:~:text=DNA%20to%20more%20damage.

However, it was a retrovirus induced lung cancer that did for her in the
end. Nothing to do with being a clone. Other sheep were also affected.

Mother Nature doesn\'t want real old people reproducing a child they\'ll never live to see through to adulthood.

What an odd claim. There are plenty of species where the previous
generation are dead and gone before the eggs of the next one even hatch!

Mayflies for example. More specifically:

https://en.wikipedia.org/wiki/Mayfly#Reproduction_and_life_cycle

--
Regards,
Martin Brown