Breathing Low Oxygen Air For Longevity...

[Fred Bloggs]

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/

 

[a a]

#dailyfakebyfred

 

[Anthony William Sloman]

On Monday, November 21, 2022 at 2:09:00 AM UTC+11, Fred Bloggs wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/

In the Urals, claiming to be older than you are to get an old age pension early was a popular sport, and claiming to be somebody else elderly who had died to keep on drawing their pension was another variation on that fraud.

Populations that have lived at high altitudes for generations have heritable adaptions that led them do well where the air is thin.The mega-rich might have to have chosen their ancestors wisely to get any of the benefits that the regime might offer.

--
Bill Sloman, Sydney

 

[John Larkin]

On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
<bloggs.fredbloggs.fred@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/

https://en.wikipedia.org/wiki/Oldest_people

 

[Fred Bloggs]

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:

On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

 

[a a]

On Monday, 21 November 2022 at 15:08:12 UTC+1, Fred Bloggs wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people
https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Fred, you can live 100 years
just stop your #dailyfakebyfred

 

[Fred Bloggs]

On Sunday, November 20, 2022 at 9:40:46 PM UTC-5, bill....@ieee.org wrote:

On Monday, November 21, 2022 at 2:09:00 AM UTC+11, Fred Bloggs wrote:
Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
In the Urals, claiming to be older than you are to get an old age pension early was a popular sport, and claiming to be somebody else elderly who had died to keep on drawing their pension was another variation on that fraud.

Populations that have lived at high altitudes for generations have heritable adaptions that led them do well where the air is thin.The mega-rich might have to have chosen their ancestors wisely to get any of the benefits that the regime might offer.

One observed association with longevity is physically hard work with limited caloric intake in youth.

This is a joke:
https://geriatrics.stanford.edu/ethnomed/african_american/fund/health_history/longevity.html

--
Bill Sloman, Sydney

 

[John Larkin]

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
<bloggs.fredbloggs.fred@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

 

[Fred Bloggs]

On Monday, November 21, 2022 at 10:04:20 AM UTC-5, John Larkin wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.
Urban legend, just not urban.

Sometimes the placebo effect makes the legend a reality.

Chinese Academy of Science -

http://www.longlonglife.org/en/transhumanism-longevity/lifespan-news/hypoxia-may-increase-lifespan/

 

[Joe Gwinn]

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
<jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fredbloggs.fred@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they world otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Joe Gwinn

 

[John Larkin]

On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joegwinn@comcast.net>
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fredbloggs.fred@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they world otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Joe Gwinn

Natural selection favors those who breed, not those who get very old.

There must be an evolutionary reason why nearly all critters get old
and die.

 

[Joe Gwinn]

On Mon, 21 Nov 2022 09:05:49 -0800, John Larkin
<jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joegwinn@comcast.net
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fredbloggs.fred@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they would otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Joe Gwinn

Natural selection favors those who breed, not those who get very old.

There must be an evolutionary reason why nearly all critters get old
and die.

Yes, but nobody really knows the reason yet, and not for lack of
trying. But it seems to be tied up in the workings of the immune
system, balancing young health against later development of cancers,
in large charismatic megafauna. The ends to which mammalian bodies go
to control cancer is astounding.

Joe Gwinn

 

[Anthony William Sloman]

On Tuesday, November 22, 2022 at 4:05:59 AM UTC+11, John Larkin wrote:

On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joeg...@comcast.net> wrote:
On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin <jla...@highlandSNIPMEtechnology.com> wrote:
On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs <bloggs.fred...@gmail.com> wrote:
On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs <bloggs.fred....@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they world otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Natural selection favors those who breed, not those who get very old.

There must be an evolutionary reason why nearly all critters get old and die.

Natural selection doesn\'t favour anybody. It is a fact that the organisms that we see are are descendants of organisms that had descendants.

Organisms that live longer than usual do have more descendants, but devoting resources to living longer doesn\'t seem to have paid off as well as devoting resources to creating more descendants when you can.

Human beings do seem to have moved to having fewer descendants and caring for them better in advanced industrial societies over the past century - the demographic transition

https://en.wikipedia.org/wiki/Demographic_transition

This may end up changing gene frequencies in the human population, but since we now seem to be in a position to edit the human genome, this effect is likely to get swamped by more-or-less intelligent design, with the the usual complication that few agree on what might constitute an intelligent design.

--
Bill Sloman, Sydney

 

[John Larkin]

On Mon, 21 Nov 2022 16:13:56 -0500, Joe Gwinn <joegwinn@comcast.net>
wrote:

On Mon, 21 Nov 2022 09:05:49 -0800, John Larkin
jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joegwinn@comcast.net
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fredbloggs.fred@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they would otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Joe Gwinn

Natural selection favors those who breed, not those who get very old.

There must be an evolutionary reason why nearly all critters get old
and die.

Yes, but nobody really knows the reason yet, and not for lack of
trying. But it seems to be tied up in the workings of the immune
system, balancing young health against later development of cancers,
in large charismatic megafauna. The ends to which mammalian bodies go
to control cancer is astounding.

Joe Gwinn

Two fairly old people can conspire and make a nice fresh baby, and
babies rarely get cancer. So clearly we have enough info in our genes
to be young.

 

[Anthony William Sloman]

On Tuesday, November 22, 2022 at 1:36:56 PM UTC+11, John Larkin wrote:

On Mon, 21 Nov 2022 16:13:56 -0500, Joe Gwinn <joeg...@comcast.net> wrote:
On Mon, 21 Nov 2022 09:05:49 -0800, John Larkin <jla...@highlandSNIPMEtechnology.com> wrote:
On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joeg...@comcast.net> wrote:
On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin <jla...@highlandSNIPMEtechnology.com> wrote:
On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs <bloggs.fred...@gmail.com> wrote:
On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they would otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Natural selection favors those who breed, not those who get very old.

There must be an evolutionary reason why nearly all critters get old
and die.

Yes, but nobody really knows the reason yet, and not for lack of
trying. But it seems to be tied up in the workings of the immune
system, balancing young health against later development of cancers,
in large charismatic megafauna. The ends to which mammalian bodies go
to control cancer is astounding.

Two fairly old people can conspire and make a nice fresh baby, and babies rarely get cancer. So clearly we have enough info in our genes to be young.

The gametes that unite to create the nice fresh baby were laid down when the fairly old people were a lot younger, and about 30% of all pregnancies end in early miscarriages, usually because the pairs of gametes that combine don\'t have all the working genes they need.

It\'s a crap shoot. Each gamete has only half the parental genes (and not the same half from one gamete to the next) so that information that is passed on is a rather idiosyncratic selection from the information available. It\'s more throwing the dice again than exploiting the information available.

The human genome is about three billion bases pairs, and there are about ten million single nuclear polymorphisms that 23 and me will tell you about if you get your own genome sequenced. Not a lot of variation - about 0.3%. Once you\'ve got stuck with a particular genome it starts getting corrupted by copying errors that can manifest themselves as cancers (though most of them don\'t). and an intelligent designer would have put in error detection and correction coding, but that would have messed up the variation that evolution depends on (if it weren\'t intelligently designed).

We could do better with better structured information, but we will probably have to work out how to get that into our cells ourselves.

Evolution isn\'t very bright.

--
Bill Sloman, Sydney

 

[Martin Brown]

On 21/11/2022 17:05, John Larkin wrote:

On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joegwinn@comcast.net
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fredbloggs.fred@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin
wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high
Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who
want to live forever Hope, hype, and self-experimentation
collided at an exclusive conference for ultra-rich
investors who want to extend their lives past 100. I went
along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/


https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044



https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat.
That may be part of it but the main influence is healthily
active lifestyle. Mountainous terrain will really kick you if
you\'re not adapted to it. Not sure about Okinawa, just small
mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they
are always hungry for significantly longer than they world
otherwise have lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Actually I think it is to a considerable extent diet related.

When I lived in Japan I lost weight and gained fitness enormously when
compared to my Western colleagues who remained based in the UK. They did
far too many business lunches and really put on the pounds.

Western diet has far too much protein and fats in it and way too much of
everything. Morbid obesity has become very common in the USA & UK.

It isn\'t surprising that if you are prepared to starve a little that a
metabolism running more slowly will last longer. The same is also true
for stars!

In animal models reduced low protein diet can increase lifespan by ~66%
mainly by reducing the oxidative load on key organs like the kidneys.

Note that this is not a trade that the rats would ever make.

Joe Gwinn

Natural selection favors those who breed, not those who get very
old.

I think you mean reproduce rather than breed. Bacteria and yeasts are
incredibly good at reproducing but seldom exchange genetic material.

They are already good enough for the niche that they occupy. Aphids and
some other insects can switch strategy between rapid all female clones
explosive population growth in the good times and sexual reproduction to
adapt in the bad.

Some cancerous cell lines are effectively immortal - at least when
cultured in vitro. They have long since killed their original host.

https://www.sciencedirect.com/topics/neuroscience/immortalised-cell-line

Cell lifetime and the number of times it can divide is governed by DNA
telemere length. Some people are genetically predisposed to live longer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370421/

There must be an evolutionary reason why nearly all critters get old
and die.

In more complex animals it is one way to shed all the parasites that
build up in a lifetime. The offspring start with a nearly clean sheet.

--
Regards,
Martin Brown

 

[John Larkin]

On Tue, 22 Nov 2022 09:34:23 +0000, Martin Brown
<\'\'\'newspam\'\'\'@nonad.co.uk> wrote:

On 21/11/2022 17:05, John Larkin wrote:
On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joegwinn@comcast.net
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fredbloggs.fred@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin
wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high
Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who
want to live forever Hope, hype, and self-experimentation
collided at an exclusive conference for ultra-rich
investors who want to extend their lives past 100. I went
along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/


https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044



https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat.
That may be part of it but the main influence is healthily
active lifestyle. Mountainous terrain will really kick you if
you\'re not adapted to it. Not sure about Okinawa, just small
mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they
are always hungry for significantly longer than they world
otherwise have lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Actually I think it is to a considerable extent diet related.

When I lived in Japan I lost weight and gained fitness enormously when
compared to my Western colleagues who remained based in the UK. They did
far too many business lunches and really put on the pounds.

Western diet has far too much protein and fats in it and way too much of
everything. Morbid obesity has become very common in the USA & UK.

It isn\'t surprising that if you are prepared to starve a little that a
metabolism running more slowly will last longer. The same is also true
for stars!

In animal models reduced low protein diet can increase lifespan by ~66%
mainly by reducing the oxidative load on key organs like the kidneys.

Note that this is not a trade that the rats would ever make.

Joe Gwinn

Natural selection favors those who breed, not those who get very
old.

I think you mean reproduce rather than breed. Bacteria and yeasts are
incredibly good at reproducing but seldom exchange genetic material.

That\'s being prissy about words. If you don\'t have kids, your gene set
is lost even if you live to 150.

You might be of some assistance to your tribe, which might outweigh
the food you waste or something, but that\'s not as effective as having
12 kids.

 

[Lamont Cranston]

Probably has to do with simulating the air in the high
Urals where people have been observed to live to 150...

Hope we live long enough to find out!
Breathing HIGH Oxygen Air For Longevity
https://www.google.com/search?client=firefox-b-1-d&q=hyperbaric+chamber+life+extension
Mikek

 

[Joe Gwinn]

On Mon, 21 Nov 2022 18:36:48 -0800, John Larkin
<jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 16:13:56 -0500, Joe Gwinn <joegwinn@comcast.net
wrote:

On Mon, 21 Nov 2022 09:05:49 -0800, John Larkin
jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joegwinn@comcast.net
wrote:

On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin
jlarkin@highlandSNIPMEtechnology.com> wrote:

On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs
bloggs.fredbloggs.fred@gmail.com> wrote:

On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larkin wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs
bloggs.fred...@gmail.com> wrote:

Probably has to do with simulating the air in the high Urals where people have been observed to live to 150...

\"Inside the billion-dollar meeting for the mega-rich who want to live forever
Hope, hype, and self-experimentation collided at an exclusive conference for ultra-rich investors who want to extend their lives past 100. I went along for the ride.\"

https://www.technologyreview.com/2022/11/16/1063300/billion-dollar-mega-rich-live-forever/
https://en.wikipedia.org/wiki/Oldest_people

https://en.wikipedia.org/wiki/Blue_zone

Apparently the Caucasus is the place to be:

https://www.verywellhealth.com/the-legendary-longevity-of-the-abkhasia-people-2224044

https://www.cnn.com/travel/article/long-life-lerik-azerbaijan-wellness/index.html

As usual the lazy westerners think it\'s something they eat. That may be part of it but the main influence is healthily active lifestyle. Mountainous terrain will really kick you if you\'re not adapted to it. Not sure about Okinawa, just small mountains there, 1700 ft.

Urban legend, just not urban.

Altitude, yes.

There is something to the part about something one eats, or rather
does not eat: It is well established with various animals that if
they get only 80% of their normal free-feeding food intake, they are
always hungry for significantly longer than they would otherwise have
lived.

So it\'s the combination of starvation (and yogurt?) that does it.

Note that this is not a trade that the rats would ever make.

Joe Gwinn

Natural selection favors those who breed, not those who get very old.

There must be an evolutionary reason why nearly all critters get old
and die.

Yes, but nobody really knows the reason yet, and not for lack of
trying. But it seems to be tied up in the workings of the immune
system, balancing young health against later development of cancers,
in large charismatic megafauna. The ends to which mammalian bodies go
to control cancer is astounding.

Joe Gwinn

Two fairly old people can conspire and make a nice fresh baby, and
babies rarely get cancer. So clearly we have enough info in our genes
to be young.

Yes. And how old we can live is also limited by things just wearing
out, even if no cancer.

But there is a twist: We wear out because the repair system also
ages, probably due to the aggregate of cancer defenses. But there are
large critters (reptiles mainly) that don\'t appear to have fixed
lifetimes, being limited by accidents and predators.

Joe Gwinn

 

[Anthony William Sloman]

On Wednesday, November 23, 2022 at 2:36:41 AM UTC+11, John Larkin wrote:

On Tue, 22 Nov 2022 09:34:23 +0000, Martin Brown <\'\'\'newspam\'\'\'@nonad.co.uk> wrote:
On 21/11/2022 17:05, John Larkin wrote:
On Mon, 21 Nov 2022 11:22:39 -0500, Joe Gwinn <joeg...@comcast.net> wrote:
On Mon, 21 Nov 2022 07:04:10 -0800, John Larkin <jla...@highlandSNIPMEtechnology.com> wrote:
On Mon, 21 Nov 2022 06:08:07 -0800 (PST), Fred Bloggs <bloggs.fred...@gmail.com> wrote:
On Sunday, November 20, 2022 at 10:54:02 PM UTC-5, John Larki wrote:
On Sun, 20 Nov 2022 07:08:56 -0800 (PST), Fred Bloggs <bloggs.fred...@gmail.com> wrote:

<snip>

Natural selection favors those who breed, not those who get very old.

I think you mean reproduce rather than breed. Bacteria and yeasts are
incredibly good at reproducing but seldom exchange genetic material.

That\'s being prissy about words.

There\'s nothing prissy about saying exactly what you mean.

> If you don\'t have kids, your gene set is lost even if you live to 150.

Your gene set is shared with your near relatives. Your kinds only get half your genome anyway. so some of it is always going to be lost.

> You might be of some assistance to your tribe, which might outweigh the food you waste or something, but that\'s not as effective as having 12 kids.

If the kids survive to an age when they reproduce and have kids of their own.

If what you do for the health of the tribe as a whole means that everybody else\'s kids get a better chance to survive and reproduce. it\'s going to outweigh having 12 sickly losers of your own.

--
Bill Sloman, Sydney