six DNA repair mechanisms identified...

[Jan Panteltje]

Researchers highlight nucleolar DNA damage response in fight against cancer
https://www.sciencedaily.com/releases/2023/03/230316113153.htm
Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways.
A new review highlights six mechanisms by which cells repair DNA damage.
By attacking these mechanisms, future applied researchers will be able to trip up cancer\'s reproduction and growth.

 

[Fred Bloggs]

On Monday, March 20, 2023 at 1:40:49 AM UTC-4, Jan Panteltje wrote:

Researchers highlight nucleolar DNA damage response in fight against cancer
https://www.sciencedaily.com/releases/2023/03/230316113153.htm
Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways.
A new review highlights six mechanisms by which cells repair DNA damage.
By attacking these mechanisms, future applied researchers will be able to trip up cancer\'s reproduction and growth.

It\'s just a review (survey) of the existing research reports, and as usual its significance is overstated.

 

[Joe Gwinn]

On Mon, 20 Mar 2023 05:40:41 GMT, Jan Panteltje <alien@comet.invalid>
wrote:

Researchers highlight nucleolar DNA damage response in fight against cancer
https://www.sciencedaily.com/releases/2023/03/230316113153.htm
Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways.
A new review highlights six mechanisms by which cells repair DNA damage.
By attacking these mechanisms, future applied researchers will be able to trip up cancer\'s reproduction and growth.

I\'m not sure what\'s new there.

A good place to look for the historical background is Doxorubicin,
specifically its mechanism of action and uses in cancer treatment.
This drug is also known as the Red Devil, and for good reason.

..< https://en.wikipedia.org/wiki/Doxorubicin >

..<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116111/#:~:text=There%20are%20two%20proposed%20mechanisms,1)%20%5B9%5D.>

Joe Gwinn

 

[Jan Panteltje]

On a sunny day (Mon, 20 Mar 2023 11:01:33 -0400) it happened Joe Gwinn
<joegwinn@comcast.net> wrote in <crsg1i910k39g1uk315vom9go9de638eu9@4ax.com>:

On Mon, 20 Mar 2023 05:40:41 GMT, Jan Panteltje <alien@comet.invalid
wrote:


Researchers highlight nucleolar DNA damage response in fight against cancer
https://www.sciencedaily.com/releases/2023/03/230316113153.htm
Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways.
A new review highlights six mechanisms by which cells repair DNA damage.
By attacking these mechanisms, future applied researchers will be able to trip up cancer\'s reproduction and growth.


I\'m not sure what\'s new there.

A good place to look for the historical background is Doxorubicin,
specifically its mechanism of action and uses in cancer treatment.
This drug is also known as the Red Devil, and for good reason.

.< https://en.wikipedia.org/wiki/Doxorubicin

.<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116111/#:~:text=There%20are%20two%20proposed%20mechanisms,1)%20%5B9%5D.

Joe Gwinn

See the paragph in the link I gave starting with:
\"
While the first four mechanisms take place inside the nucleolus,
which is in a room cordoned off within the watery cell,
the last two mechanisms use a new cellular process which won the 2023 Breakthrough Prize in Life Sciences.
.... -----
\"What\'s new is that APE1 acts like a GPS or a first responder,\"
Yan said. \"It says there\'s a problem here, we need a police car, a medic, and others to come and be concentrated here.\"



In the process, called liquid-liquid phase transition,
proteins pop up their own liquid \'tents\' to do their work instead of staying inside a room.\"



Its very intersting how many DNA repair mechanisms exist!

 

[Ricky]

On Monday, March 20, 2023 at 11:23:39 AM UTC-4, Jan Panteltje wrote:

On a sunny day (Mon, 20 Mar 2023 11:01:33 -0400) it happened Joe Gwinn
joeg...@comcast.net> wrote in <crsg1i910k39g1uk3...@4ax.com>:
On Mon, 20 Mar 2023 05:40:41 GMT, Jan Panteltje <al...@comet.invalid
wrote:


Researchers highlight nucleolar DNA damage response in fight against cancer
https://www.sciencedaily.com/releases/2023/03/230316113153.htm
Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways.
A new review highlights six mechanisms by which cells repair DNA damage..
By attacking these mechanisms, future applied researchers will be able to trip up cancer\'s reproduction and growth.


I\'m not sure what\'s new there.

A good place to look for the historical background is Doxorubicin,
specifically its mechanism of action and uses in cancer treatment.
This drug is also known as the Red Devil, and for good reason.

.< https://en.wikipedia.org/wiki/Doxorubicin

.<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116111/#:~:text=There%20are%20two%20proposed%20mechanisms,1)%20%5B9%5D.

Joe Gwinn
See the paragph in the link I gave starting with:
\"
While the first four mechanisms take place inside the nucleolus,
which is in a room cordoned off within the watery cell,
the last two mechanisms use a new cellular process which won the 2023 Breakthrough Prize in Life Sciences.
... -----
\"What\'s new is that APE1 acts like a GPS or a first responder,\"
Yan said. \"It says there\'s a problem here, we need a police car, a medic, and others to come and be concentrated here.\"



In the process, called liquid-liquid phase transition,
proteins pop up their own liquid \'tents\' to do their work instead of staying inside a room.\"



Its very intersting how many DNA repair mechanisms exist!

Tons of redundancy in nature. Stuff was designed by random combinations of DNA and mutations. So you figure there\'s going to be lots of oddities involved.

There was a circuit designed by the equivalent of random mutations in a computer program. It would make random changes, then run a simulation and evaluate the result against a set of requirements. It came up with a result that matched the requirements pretty well, but had glitches. There was no logic to the design. It just worked... mostly.

I wonder what would happen if this were done with a larger system and included the equivalent of DNA recombination. It would also be interesting to include populations, where the evaluation of the resulting program involved interactions between multiple copies. In other words, approximate what we think we see in sexual reproduction.

It\'s hard to believe the process of procreation is as complex as it is, without a good reason.

--

Rick C.

- Get 1,000 miles of free Supercharging
- Tesla referral code - https://ts.la/richard11209

 

[Joe Gwinn]

On Mon, 20 Mar 2023 09:25:09 -0700 (PDT), Ricky
<gnuarm.deletethisbit@gmail.com> wrote:

On Monday, March 20, 2023 at 11:23:39?AM UTC-4, Jan Panteltje wrote:
On a sunny day (Mon, 20 Mar 2023 11:01:33 -0400) it happened Joe Gwinn
joeg...@comcast.net> wrote in <crsg1i910k39g1uk3...@4ax.com>:
On Mon, 20 Mar 2023 05:40:41 GMT, Jan Panteltje <al...@comet.invalid
wrote:


Researchers highlight nucleolar DNA damage response in fight against cancer
https://www.sciencedaily.com/releases/2023/03/230316113153.htm
Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways.
A new review highlights six mechanisms by which cells repair DNA damage.
By attacking these mechanisms, future applied researchers will be able to trip up cancer\'s reproduction and growth.


I\'m not sure what\'s new there.

A good place to look for the historical background is Doxorubicin,
specifically its mechanism of action and uses in cancer treatment.
This drug is also known as the Red Devil, and for good reason.

.< https://en.wikipedia.org/wiki/Doxorubicin

.<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116111/#:~:text=There%20are%20two%20proposed%20mechanisms,1)%20%5B9%5D.

Joe Gwinn
See the paragph in the link I gave starting with:
\"
While the first four mechanisms take place inside the nucleolus,
which is in a room cordoned off within the watery cell,
the last two mechanisms use a new cellular process which won the 2023 Breakthrough Prize in Life Sciences.
... -----
\"What\'s new is that APE1 acts like a GPS or a first responder,\"
Yan said. \"It says there\'s a problem here, we need a police car, a medic, and others to come and be concentrated here.\"



In the process, called liquid-liquid phase transition,
proteins pop up their own liquid \'tents\' to do their work instead of staying inside a room.\"



Its very intersting how many DNA repair mechanisms exist!

Tons of redundancy in nature. Stuff was designed by random combinations of DNA and mutations. So you figure there\'s going to be lots of oddities involved.

There was a circuit designed by the equivalent of random mutations in a computer program. It would make random changes, then run a simulation and evaluate the result against a set of requirements. It came up with a result that matched the requirements pretty well, but had glitches. There was no logic to the design. It just worked... mostly.

I wonder what would happen if this were done with a larger system and included the equivalent of DNA recombination. It would also be interesting to include populations, where the evaluation of the resulting program involved interactions between multiple copies. In other words, approximate what we think we see in sexual reproduction.

It\'s hard to believe the process of procreation is as complex as it is, without a good reason.

..<https://en.wikipedia.org/wiki/John_Henry_Holland>

Joe Gwinn

 

[Jan Panteltje]

On a sunny day (Mon, 20 Mar 2023 09:25:09 -0700 (PDT)) it happened Ricky
<gnuarm.deletethisbit@gmail.com> wrote in
<d3600990-6dff-4fa0-b384-59bb213fb642n@googlegroups.com>:

On Monday, March 20, 2023 at 11:23:39 AM UTC-4, Jan Panteltje wrote=
:
On a sunny day (Mon, 20 Mar 2023 11:01:33 -0400) it happened Joe Gwinn
joeg...@comcast.net> wrote in <crsg1i910k39g1uk3...@4ax.com>:
On Mon, 20 Mar 2023 05:40:41 GMT, Jan Panteltje <al...@comet.invalid
wrote:


Researchers highlight nucleolar DNA damage response in fight against ca=
ncer
https://www.sciencedaily.com/releases/2023/03/230316113153.htm
Researchers have now encapsulated the young field of nucleolar DNA dama=
ge response (DDR) pathways.
A new review highlights six mechanisms by which cells repair DNA damage=
.
By attacking these mechanisms, future applied researchers will be able =
to trip up cancer\'s reproduction and growth.


I\'m not sure what\'s new there.

A good place to look for the historical background is Doxorubicin,
specifically its mechanism of action and uses in cancer treatment.
This drug is also known as the Red Devil, and for good reason.

.< https://en.wikipedia.org/wiki/Doxorubicin

.<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116111/#:~:text=There%=
20are%20two%20proposed%20mechanisms,1)%20%5B9%5D.

Joe Gwinn
See the paragph in the link I gave starting with:
\"
While the first four mechanisms take place inside the nucleolus,
which is in a room cordoned off within the watery cell,
the last two mechanisms use a new cellular process which won the 2023 Bre=
akthrough Prize in Life Sciences.
... -----
\"What\'s new is that APE1 acts like a GPS or a first responder,\"
Yan said. \"It says there\'s a problem here, we need a police car, a medic,=
and others to come and be concentrated here.\"



In the process, called liquid-liquid phase transition,
proteins pop up their own liquid \'tents\' to do their work instead of stay=
ing inside a room.\"



Its very interesting how many DNA repair mechanisms exist!

Tons of redundancy in nature. Stuff was designed by random combinations of=
DNA and mutations. So you figure there\'s going to be lots of oddities inv=
olved.

There was a circuit designed by the equivalent of random mutations in a com=
puter program. It would make random changes, then run a simulation and eva=
luate the result against a set of requirements. It came up with a result t=
hat matched the requirements pretty well, but had glitches. There was no l=
ogic to the design. It just worked... mostly.

I wonder what would happen if this were done with a larger system and inclu=
ded the equivalent of DNA recombination. It would also be interesting to i=
nclude populations, where the evaluation of the resulting program involved =
interactions between multiple copies. In other words, approximate what we=
think we see in sexual reproduction.

It\'s hard to believe the process of procreation is as complex as it is, wit=
hout a good reason.

Yes, ever more complex, look at our societies
one designs something. some communicate it to others, some build things, some fix things, some maintain
or heal all those that do things...
In essence \'communication\' is possibly the thing that makes it all work,
from an electron orbiting a nucleus (hold together by electric forces etc) to our societies.

All that from what came out of the big bang... if there was one.
One thing depending on the other,
we \'keep\' (beware of the word as slave) the microbes in our guts
- the real word is \'symbiosis\'.
We feed them, they gives us energy..
Goes for every cell and part of every cell too I\'d think, down again to the subatomic level.

 

[Fred Bloggs]

On Monday, March 20, 2023 at 11:01:51 AM UTC-4, Joe Gwinn wrote:

On Mon, 20 Mar 2023 05:40:41 GMT, Jan Panteltje <al...@comet.invalid
wrote:

Researchers highlight nucleolar DNA damage response in fight against cancer
https://www.sciencedaily.com/releases/2023/03/230316113153.htm
Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways.
A new review highlights six mechanisms by which cells repair DNA damage.
By attacking these mechanisms, future applied researchers will be able to trip up cancer\'s reproduction and growth.
I\'m not sure what\'s new there.

A good place to look for the historical background is Doxorubicin,
specifically its mechanism of action and uses in cancer treatment.
This drug is also known as the Red Devil, and for good reason.

.< https://en.wikipedia.org/wiki/Doxorubicin

.<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116111/#:~:text=There%20are%20two%20proposed%20mechanisms,1)%20%5B9%5D.

Highly toxic 70 year old microbial toxin selected because the bacteria was red? Not a good example. Half a step up from a 19th century concoction of arsenic, more bio-alchemy than pharmacology.

Joe Gwinn