OT: B.1.1.529 variant has 50 mutations overall,... 30 on spike protein alone...

[Rick C]

\"There are also 10 mutations on the receptor binding domain part of the variant, compared to two for the Delta variant\"

\"looks like vaccine evasion could be real with this variant\"

So much for the spike protein being heavily conserved. The amino acids can change as long as they work the same way or better.

Looks like we are going to have a nice holiday surprise!

--

Rick C.

- Get 1,000 miles of free Supercharging
- Tesla referral code - https://ts.la/richard11209

 

[Anthony William Sloman]

On Friday, November 26, 2021 at 4:54:40 PM UTC+11, gnuarm.del...@gmail.com wrote:

\"There are also 10 mutations on the receptor binding domain part of the variant, compared to two for the Delta variant\"

\"looks like vaccine evasion could be real with this variant\"

So much for the spike protein being heavily conserved. The amino acids can change as long as they work the same way or better.

But they won\'t work if they change the shape of the protein - because then it can\'t dock on the ACE-2 receptor - and shape is pretty much what antibodies are binding onto.

> Looks like we are going to have a nice holiday surprise!

It\'s always possible, but counting mutations in the receptor binding domain isn\'t a good way of predicting one. The mRNA vaccines and Astra-Zeneca vaccine use the whole spike protein as their antigen - not just the receptor binding domain - and the spike protein acts as can-open to get into the target cell after the binding domain has latched onto the ACE-2 receptor, which constrains it\'s structure even more.

--
Bill Sloman, Sydney

 

[Jan Panteltje]

On a sunny day (Thu, 25 Nov 2021 22:35:49 -0800 (PST)) it happened Anthony
William Sloman <bill.sloman@ieee.org> wrote in
<c105ced9-27ce-424c-bbc7-c7a1417f9cd5n@googlegroups.com>:

On Friday, November 26, 2021 at 4:54:40 PM UTC+11, gnuarm.del...@gmail.com wrote:

\"There are also 10 mutations on the receptor binding domain part of the variant,
compared to two for the Delta variant\"

\"looks like vaccine evasion could be real with this variant\"

So much for the spike protein being heavily conserved. The amino acids can
change as long as they work the same way or better.

But they won\'t work if they change the shape of the protein - because then it
can\'t dock on the ACE-2 receptor - and shape is pretty much what antibodies
are binding onto.

Looks like we are going to have a nice holiday surprise!

It\'s always possible, but counting mutations in the receptor binding domain
isn\'t a good way of predicting one. The mRNA vaccines and Astra-Zeneca vaccine
use the whole spike protein as their antigen - not just the receptor binding
domain - and the spike protein acts as can-open to get into the target
cell after the binding domain has latched onto the ACE-2 receptor, which
constrains it\'s structure even more.

Hacked emails from Dr Faulty to NASA show he expects because of the new Africa covid variant
that spacesuits will be required for all of humanity, mouthcaps will no longer suffice.
These suits will have to be worn 24/7, but there will be openings for food, feces and sex.

 

[Fred Bloggs]

On Friday, November 26, 2021 at 12:54:40 AM UTC-5, gnuarm.del...@gmail.com wrote:

\"There are also 10 mutations on the receptor binding domain part of the variant, compared to two for the Delta variant\"

\"looks like vaccine evasion could be real with this variant\"

So much for the spike protein being heavily conserved. The amino acids can change as long as they work the same way or better.

Looks like we are going to have a nice holiday surprise!

The scientific community doesn\'t want to risk downplaying it, but it\'s not amounting to much. Right now now it\'s circulating in small numbers in areas where it could have blown out of sight into a huge epidemic, but it hasn\'t..
Sheer numbers of mutation tell you nothing, it is much more complicated than that. It\'s very difficult to configure this virus to have the ability to infect human cells. That\'s why it took the American bioweapon scientists so long to get this working.
Once again, the vaccines DO NOT use the spike protein to induce the antibody response. They use a modified spike protein locked open to put the RBD on display, and it\'s the RBD that induces the antibodies. Without the relatively huge spike protein, the immune system would not detect and be drawn into to reacting with the RBD on its own. Any antibodies generated for anti-spike proteins are incidental, unwanted and in some cases outright dangerous, at least one anti-N capsid protein enhances infection.
This is an example of just another variant being spawned by a huge population of unvaccinated people, stressing the importance of acquiring some kind of immunity on a global scale. Apparently it doesn\'t take a radically effective immunity, even a modest amount goes a long way in preventing a new outbreak.

https://www.bbc.com/news/uk-59424269

Now that the major players like Pfizer are bring highly effective antiviral meds to the market, they\'ll be able to absolutely crush any breakthrough infection. The science of preventing drug resistant strains is well known now and not expected to become a problem.
https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

Most previous attempts at this were repurposed ebola drugs, none of which have worked worth a damn. Pfizer\'s drug is specialized for SARS-Cov2 and more are sure to follow.

--

Rick C.

- Get 1,000 miles of free Supercharging
- Tesla referral code - https://ts.la/richard11209

 

[bitrex]

On 11/26/2021 6:50 AM, Fred Bloggs wrote:

On Friday, November 26, 2021 at 12:54:40 AM UTC-5, gnuarm.del...@gmail.com wrote:
\"There are also 10 mutations on the receptor binding domain part of the variant, compared to two for the Delta variant\"

\"looks like vaccine evasion could be real with this variant\"

So much for the spike protein being heavily conserved. The amino acids can change as long as they work the same way or better.

Looks like we are going to have a nice holiday surprise!

The scientific community doesn\'t want to risk downplaying it, but it\'s not amounting to much. Right now now it\'s circulating in small numbers in areas where it could have blown out of sight into a huge epidemic, but it hasn\'t.
Sheer numbers of mutation tell you nothing, it is much more complicated than that. It\'s very difficult to configure this virus to have the ability to infect human cells. That\'s why it took the American bioweapon scientists so long to get this working.
Once again, the vaccines DO NOT use the spike protein to induce the antibody response. They use a modified spike protein locked open to put the RBD on display, and it\'s the RBD that induces the antibodies. Without the relatively huge spike protein, the immune system would not detect and be drawn into to reacting with the RBD on its own. Any antibodies generated for anti-spike proteins are incidental, unwanted and in some cases outright dangerous, at least one anti-N capsid protein enhances infection.
This is an example of just another variant being spawned by a huge population of unvaccinated people, stressing the importance of acquiring some kind of immunity on a global scale. Apparently it doesn\'t take a radically effective immunity, even a modest amount goes a long way in preventing a new outbreak.

https://www.bbc.com/news/uk-59424269

Now that the major players like Pfizer are bring highly effective antiviral meds to the market, they\'ll be able to absolutely crush any breakthrough infection. The science of preventing drug resistant strains is well known now and not expected to become a problem.
https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

Most previous attempts at this were repurposed ebola drugs, none of which have worked worth a damn. Pfizer\'s drug is specialized for SARS-Cov2 and more are sure to follow.

So did \"they\" release the virus at the Wuhan meat market? As I\'ve read
that in retrospective analysis the distribution of early cases seems to
conclusively point back to the Wuhan market as the putative origin.

 

[Ed Lee]

On Friday, November 26, 2021 at 6:47:31 AM UTC-8, bitrex wrote:

On 11/26/2021 6:50 AM, Fred Bloggs wrote:
On Friday, November 26, 2021 at 12:54:40 AM UTC-5, gnuarm.del...@gmail.com wrote:
\"There are also 10 mutations on the receptor binding domain part of the variant, compared to two for the Delta variant\"

\"looks like vaccine evasion could be real with this variant\"

So much for the spike protein being heavily conserved. The amino acids can change as long as they work the same way or better.

Looks like we are going to have a nice holiday surprise!

The scientific community doesn\'t want to risk downplaying it, but it\'s not amounting to much. Right now now it\'s circulating in small numbers in areas where it could have blown out of sight into a huge epidemic, but it hasn\'t.
Sheer numbers of mutation tell you nothing, it is much more complicated than that. It\'s very difficult to configure this virus to have the ability to infect human cells. That\'s why it took the American bioweapon scientists so long to get this working.
Once again, the vaccines DO NOT use the spike protein to induce the antibody response. They use a modified spike protein locked open to put the RBD on display, and it\'s the RBD that induces the antibodies. Without the relatively huge spike protein, the immune system would not detect and be drawn into to reacting with the RBD on its own. Any antibodies generated for anti-spike proteins are incidental, unwanted and in some cases outright dangerous, at least one anti-N capsid protein enhances infection.
This is an example of just another variant being spawned by a huge population of unvaccinated people, stressing the importance of acquiring some kind of immunity on a global scale. Apparently it doesn\'t take a radically effective immunity, even a modest amount goes a long way in preventing a new outbreak.

https://www.bbc.com/news/uk-59424269

Now that the major players like Pfizer are bring highly effective antiviral meds to the market, they\'ll be able to absolutely crush any breakthrough infection. The science of preventing drug resistant strains is well known now and not expected to become a problem.
https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

Most previous attempts at this were repurposed ebola drugs, none of which have worked worth a damn. Pfizer\'s drug is specialized for SARS-Cov2 and more are sure to follow.
So did \"they\" release the virus at the Wuhan meat market? As I\'ve read
that in retrospective analysis the distribution of early cases seems to
conclusively point back to the Wuhan market as the putative origin.

It\'s an coordinated release to drive down energy price. SPR release didn\'t work. So, this super virus scare did some.

 

[Fred Bloggs]

On Friday, November 26, 2021 at 9:40:57 PM UTC-5, bill....@ieee.org wrote:


Just STFU damned ignorant simple minded ass. All you know is some very fundamental concepts much of which don\'t apply here. You haven\'t been following the literature so you don\'t know anything- haven\'t paid your dues iow. Feel free to snow some parking lot attendant or hot dog concessionaire or similar simpleton with your \"expertise.\"

--
Bill Sloman, Sydney

 

[Anthony William Sloman]

On Saturday, November 27, 2021 at 1:49:59 PM UTC+11, Fred Bloggs wrote:

On Friday, November 26, 2021 at 9:40:57 PM UTC-5, bill....@ieee.org wrote:

Just STFU damned ignorant simple minded ass. All you know is some very fundamental concepts much of which don\'t apply here. You haven\'t been following the literature so you don\'t know anything - haven\'t paid your dues iow. Feel free to snow some parking lot attendant or hot dog concessionaire or similar simpleton with your \"expertise.\"

Fred doesn\'t like it when he is shown up. He gets seriously upset. His own capacity for \"following the literature\" is compromised by the fact that he can\'t understand most of it.

I\'m not sure that he ever understood that \"highly conserved\" doesn\'t mean \"doesn\'t mutate\", when it actually means that most of the mutations that happen in a highly conserved area of the genome turn out to be lethal, and don\'t get propagated.

--
Bill Sloman, Sydney