Human Aging Now Biologically Reversible...

F

Fred Bloggs

Guest
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
 
On 11/27/20 5:15 PM, Dean Hoffman wrote:
On 11/27/20 8:32 AM, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT),
telomere length was significantly increased and senescent cells were
reduced in a population of healthy aging subjects. The study, part of
a comprehensive research program targeting aging as a reversible
disease, is to be published in the peer-review journal Aging, and
titled: Hyperbaric Oxygen Therapy Increases Telomere Length and
Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html


      Is it a good thing if true?  Kids challenge authority and push
change.
Old people:  \"We\'ve always done it this way\".  Where would we be without
Rock \'Em Sock \'Em Robots and Superball?
http://content.time.com/time/specials/packages/0,28757,2049243,00.html
Click to expand...

The elephant in the room problem is that if old people can hang around
indefinitely, there must be a reduction in the introduction of new
(young) people, or we run out of resources for species survival.
 
On Saturday, November 28, 2020 at 2:31:48 PM UTC+11, Bill Martin wrote:
On 11/27/20 5:15 PM, Dean Hoffman wrote:
On 11/27/20 8:32 AM, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT),
telomere length was significantly increased and senescent cells were
reduced in a population of healthy aging subjects. The study, part of
a comprehensive research program targeting aging as a reversible
disease, is to be published in the peer-review journal Aging, and
titled: Hyperbaric Oxygen Therapy Increases Telomere Length and
Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html


Is it a good thing if true? Kids challenge authority and push
change.
Old people: \"We\'ve always done it this way\". Where would we be without
Rock \'Em Sock \'Em Robots and Superball?
http://content.time.com/time/specials/packages/0,28757,2049243,00.html

The elephant in the room problem is that if old people can hang around
indefinitely, there must be a reduction in the introduction of new
(young) people, or we run out of resources for species survival.
Click to expand...

This is Fred Bloggs. Even if he has got it right, and a few people are going to live a bit longer, it just going to be part of the recent improvement in life expectancy, which started around 1870 in advanced industrial countries, if not until in1925 in Africa, and still seems to be going on.

https://ourworldindata.org/life-expectancy
The consequence in advanced in most advanced industrial countries - the US may be industrial but it\'s not all that advanced - was that their birth rates has dropped below replacement level, and population growth - if any - is driven by immigration from less advanced countries.

We may run short on resources, but the species should survive - albeit perhaps with a winnowed gene pool.

--
Bill Sloman, Sydney
 
On Fri, 27 Nov 2020 06:32:27 -0800 (PST), Fred Bloggs
<bloggs.fredbloggs.fred@gmail.com> wrote:

Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
Click to expand...
Also here
https://medicalxpress.com/news/2020-11-hyperbaric-oxygen-treatments-reverse-aging.html
 
On Friday, November 27, 2020 at 9:32:35 AM UTC-5, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
Click to expand...
Huh, OK... I thought telomere length was something set in your genes... DNA..
My limited understanding is that it\'s like the max_count(N) number in a for loop.
Copy this piece of genetic code N times, then no more.
Evolution-wise it stops uncontrolled replication of one of your cells. (cancer)
Hmm.. OK oxidative state may change \'extra\' damage/ shortening.
https://en.wikipedia.org/wiki/Telomere#Shortening

Maybe the main benefit of exercise is keeping more oxygen in your blood?
I\'m going out to lift and carry more pieces of wood into my truck. :^)

George H.
 
On 11/27/2020 12:59 PM, George Herold wrote:
On Friday, November 27, 2020 at 9:32:35 AM UTC-5, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
Huh, OK... I thought telomere length was something set in your genes... DNA.
My limited understanding is that it\'s like the max_count(N) number in a for loop.
Copy this piece of genetic code N times, then no more.
Evolution-wise it stops uncontrolled replication of one of your cells. (cancer)
Hmm.. OK oxidative state may change \'extra\' damage/ shortening.
https://en.wikipedia.org/wiki/Telomere#Shortening

Maybe the main benefit of exercise is keeping more oxygen in your blood?
I\'m going out to lift and carry more pieces of wood into my truck. :^)

George H.
Click to expand...

Competing with 30 year olds on the dating circuit was tough enough, now
have to compete with 70 y/os too!

The future is going to be a good time to be a 40 y/o single woman
 
On Friday, November 27, 2020 at 12:59:08 PM UTC-5, George Herold wrote:
On Friday, November 27, 2020 at 9:32:35 AM UTC-5, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
Huh, OK... I thought telomere length was something set in your genes... DNA.
My limited understanding is that it\'s like the max_count(N) number in a for loop.
Copy this piece of genetic code N times, then no more.
Evolution-wise it stops uncontrolled replication of one of your cells. (cancer)
Hmm.. OK oxidative state may change \'extra\' damage/ shortening.
https://en.wikipedia.org/wiki/Telomere#Shortening
Click to expand...

My understanding is there is an unknown chemistry of the telomere reading its substrate that controls everything replication related. The telomere making mistakes, which increase in frequency with shortening, is how you end up with all this age related cellular damage.

Maybe the main benefit of exercise is keeping more oxygen in your blood?
I\'m going out to lift and carry more pieces of wood into my truck. :^)

George H.
Click to expand...
 
On Friday, November 27, 2020 at 1:54:39 PM UTC-5, bitrex wrote:
On 11/27/2020 12:59 PM, George Herold wrote:
On Friday, November 27, 2020 at 9:32:35 AM UTC-5, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
Huh, OK... I thought telomere length was something set in your genes... DNA.
My limited understanding is that it\'s like the max_count(N) number in a for loop.
Copy this piece of genetic code N times, then no more.
Evolution-wise it stops uncontrolled replication of one of your cells. (cancer)
Hmm.. OK oxidative state may change \'extra\' damage/ shortening.
https://en.wikipedia.org/wiki/Telomere#Shortening

Maybe the main benefit of exercise is keeping more oxygen in your blood?
I\'m going out to lift and carry more pieces of wood into my truck. :^)

George H.



Competing with 30 year olds on the dating circuit was tough enough, now
have to compete with 70 y/os too!

The future is going to be a good time to be a 40 y/o single woman
Click to expand...

They\'ll all be like Dolly- a new body with old genes.
 
On Friday, November 27, 2020 at 2:22:21 PM UTC-5, Fred Bloggs wrote:
On Friday, November 27, 2020 at 12:59:08 PM UTC-5, George Herold wrote:
On Friday, November 27, 2020 at 9:32:35 AM UTC-5, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
Huh, OK... I thought telomere length was something set in your genes... DNA.
My limited understanding is that it\'s like the max_count(N) number in a for loop.
Copy this piece of genetic code N times, then no more.
Evolution-wise it stops uncontrolled replication of one of your cells. (cancer)
Hmm.. OK oxidative state may change \'extra\' damage/ shortening.
https://en.wikipedia.org/wiki/Telomere#Shortening
My understanding is there is an unknown chemistry of the telomere reading its substrate that controls everything replication related. The telomere making mistakes, which increase in frequency with shortening, is how you end up with all this age related cellular damage.
Click to expand...

Do you know the story about the (inadvertent) selection for long telomeres in US lab mice?
(They only breed young males and females \'cause they had the most offspring..)
search for \"all of our mice are broken\"

George H.

Maybe the main benefit of exercise is keeping more oxygen in your blood?
I\'m going out to lift and carry more pieces of wood into my truck. :^)

George H.
Click to expand...
 
On Fri, 27 Nov 2020 09:59:02 -0800 (PST), George Herold
<ggherold@gmail.com> wrote:

On Friday, November 27, 2020 at 9:32:35 AM UTC-5, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
Huh, OK... I thought telomere length was something set in your genes... DNA.
My limited understanding is that it\'s like the max_count(N) number in a for loop.
Copy this piece of genetic code N times, then no more.
Evolution-wise it stops uncontrolled replication of one of your cells. (cancer)
Hmm.. OK oxidative state may change \'extra\' damage/ shortening.
https://en.wikipedia.org/wiki/Telomere#Shortening

Maybe the main benefit of exercise is keeping more oxygen in your blood?
I\'m going out to lift and carry more pieces of wood into my truck. :^)
Click to expand...

I cannot see how this can work. I\'d wait to see if anybody can
replicate the experiment a few times.

Telomere length is controlled by an enzyme, telomerase, which in
mammals is turned off, which is the underlying cause of the count
limit.

..<https://en.wikipedia.org/wiki/Telomerase>

There was in 2010 an experiment in generically-engineered mice where
telomerase was turned back on for a while. Aging was partly reversed
- gray hair went back to black, and so on.

..<https://www.nature.com/articles/s41467-019-12664-x>

..<https://www.wsj.com/articles/SB10001424052748703785704575642964209242180>

So, why is telomerase turned off at all? It appears to be one of the
many evolved anti-cancer measures that all big complicated animals
must have t o have a reasonable lifespan.

Joe Gwinn
 
On 28/11/20 4:59 am, George Herold wrote:
On Friday, November 27, 2020 at 9:32:35 AM UTC-5, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
Huh, OK... I thought telomere length was something set in your genes... DNA.
Click to expand...

You can increase the average length by replacing cells that have short
telomeres with cells that have longer ones - by activating replication
in residual populations that have longer ones. Pure speculation, but
it\'s plausible.

CH
 
On 11/27/20 8:32 AM, Fred Bloggs wrote:
Oh Joy!

\"Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.\"

https://www.prnewswire.com/il/news-releases/first-time-human-study-shows-reversal-in-biology-of-aging--telomere-shortening-and-senescent-cells-accumulation--with-hyperbaric-oxygen-therapy-hbot-301176053.html
Click to expand...
Is it a good thing if true? Kids challenge authority and push
change.
Old people: \"We\'ve always done it this way\". Where would we be without
Rock \'Em Sock \'Em Robots and Superball?
<http://content.time.com/time/specials/packages/0,28757,2049243,00.html>
 
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